摘要
目的:探讨了鼻咽癌患者血清TGF-β1、IL-8和T淋巴细胞亚群水平的变化及意义。方法:分别应用放免法、酶联免疫法和单克隆抗体测定对31例鼻咽癌患者进行了血清TGF-β1、IL-8水平和T淋巴细胞亚群的测定,并与35例正常健康人作比较。结果:鼻咽癌患者血清TGF-β1、IL-8和CD8水平非常显著高于正常人组(P<0.01),而CD3、CD4、CD4/CD8比值又非常显著低于正常人组(P<0.01)。鼻咽癌患者血清TGF-β1水平和CD4细胞数量及与CD4/CD8比值呈负相关,与CD8细胞呈正相关。结论:观察鼻咽癌患者血清TGF-β1、IL-8水平和T淋巴细胞亚群水平的改变有助于鼻咽癌的诊断及对预后的评价。
Objective To explore the significance of changes of serum transform growth factor β1 (TGF - β1) and IL - 8 as well as T cell subsets distribution type in patients with nasopharangeal carcinoma. Methods Serum TGF - β1 (with ELISA), IL - 8 (with RIA) levels and T cell subsets distribution type (with monoclonal antibody technique) were determined in 31 patients with nasopharangeal carcinoma as well as in 35 controls. Results The serum levels of TGF - β1, IL - 8 and CD8 percentage were significantly higher in the patients than those in controls (P 〈 0.01), while CD3, CD4 percentage and CD4/CD8 ratio were significantly lower (P 〈 0.01). In the patients, the serum TGF - β1 levels were positively correlated with CD8 percentage and negatively correlated with CD4 percentage and CD4/CD8 ratio. Conclusion The altered levels of TGF - β1 and IL - 8 as well as the decrease of CD4/CD8 were correlated with the clinical development and prognosis in patients with nasopharangeal carcinoma.
出处
《放射免疫学杂志》
CAS
2006年第5期372-373,共2页
Journal of Radioimmanology