肺癌患者在输红细胞治疗前后血清SOD和T淋巴细胞亚群检测的临床意义

Clinical Significance of Determination of Changes of Serum SOD and T-cell Subsets Distribution Type After Leukocyte-Deduced Red Blood Cell Transfusion in Patients with Lung Cancer

目的:探讨了肺癌患者在输红细胞治疗前后血清SOD和T淋巴细胞亚群分布状况的改变。方法:分别应用放射免疫分析和单克隆抗体法对32例肺癌患者进行了血清SOD和T淋巴细胞亚群的检测,并与35名正常人作比较。结果:肺癌患者在治疗前血清SOD、T淋巴细胞CD4/CD8值显著低于正常人组(P<0.01),经输红细胞治疗后1个月则与正常人组比较无显著性差异(P>0.05)。结论:检测肺癌患者输红细胞治疗前后血清SOD和T淋巴细胞亚群的水平对其病情和预后判断均具有重要的临床价值。

Objective To investigate the changes of serum SOD contents and T - cell subsets distribution type after leukocyte - deduced red blood cell transfusion in patients with lung cancer. Methods Serum SOD levels was measured with RIA and T - cell subsets distribution type was detected with monoclonal antibody technic both before and after leukocyte - deduced red blood cell transfusion in 32 patients with lung cancer and 35 normal controls. Results Before treatment, the serum levels of SOD and T - cell CD4/CD8 value were significantly lower in the patients than those in controls （P 〈 0.01）. One month after leukocyte - deduced red blood cell transfusion the serum SOD level and CD4/CD8 value returned to normal with no significant difference from those in controls （P 〉 0.05）. Conclusion Determination of serum SOD level and T - cell subsets distribution type is clinically useful in the management of patients with lung cancer.