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胎盘生长因子(PLGF)及其受体血管内皮生长因子受体-1(VEGFR-1)在子宫内膜异位症中的表达及意义 被引量：5

The expression of PLGF and VEGFR-1 in endometriosis
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摘要 目的探讨胎盘生长因子(PLGF)及其受体血管内皮生长因子受体-1(VEGFR-1)与子宫内膜异位症(endom etriosis,EMS)发病的相关性。方法用免疫组织化学染色法检测28例子宫内膜异位症患者的在位子宫内膜和异位子宫内膜(增生期、分泌期各14例),以及28例正常子宫内膜(增生期15例,分泌期13例)中PLGF及其受体VEGFR-1的表达。结果PLGF、VEGFR-1在各组内膜中均有表达,分泌期表达高于增生期,有显著差异。EMS的异位子宫内膜中的表达显著高于其在位子宫内膜和正常子宫内膜;EMS的在位子宫内膜和正常子宫内膜之间比较无明显差异。结论PLGF、VEGFR-1可能参与子宫内膜异位症的发病过程。 Objective： To investigate the expression of PLGF and V EGFR - 1 in endometriosis. Methods： Expression of PLGF and VEGFR - 1 in eetopic and eutopic endometrium of endometriosis was assessed by the immuno - histochemistry. Results： Expression of PLGF and VEGFR - 1 in eetopic endometrium group were significant higher than that in euptic endometrium group and normal endometrium group. Conclusion ： The higher expression of PLGF and VEGFR - 1 in ectopie endometrium with endometriosis indicates they may play a important role in the pathophysiology and development of endometriosis.
作者 王竹辉 何福仙
机构地区 华中科技大学同济医学院附属同济医院妇产科
出处 《中国优生与遗传杂志》 2006年第10期17-18,16,共3页 Chinese Journal of Birth Health & Heredity
关键词 子宫内膜异位症 PLGF VEGFR-1 Endometriosis PLGF VEGFR- 1
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献8

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共引文献12

同被引文献52

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引证文献5

二级引证文献11

中国优生与遗传杂志
2006年 第10期

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