摘要
目的探讨低剂量电离辐射与细胞减数分裂染色体不分离的关系。方法7～8w ICR雌性小鼠经PMGS和hCG促排卵后分别给予不同剂量（〈1．5Gy）及相同剂量不同次数的Cs^137 γ-射线照射后使其与同龄未受照射雄鼠交配，17—19d后取胎鼠的上皮组织进行细胞培养，制备染色体标本并观察、计数。结果母鼠经电离辐射后，子代体细胞中染色体非整倍体率和超二倍体率明显增高，且呈现剂量-相应和次数-相应。结论低剂量电离辐射是引起卵细胞染色体不分离的重要环境因子。
Objective ： To explore the relationship between ionizing radiation and meiotic chromosome non - disjunction. Methods ： The female mice aged 7 -8 weeks were treated under low dose of Cs^137γ -ray before fertilization , the cells of embryo were cultured and metaphase chromosome number was measured and statistically analyzed. Results： The rate of meiosis chromosome non - disjunction of the groups under irradiation is higher than that of control group. And the effect is dose - dependent and accumulated. Conclusion： Low dose irradiation can cause meiotic chromosome non- disjunction.
出处
《中国优生与遗传杂志》
2006年第10期24-25,共2页
Chinese Journal of Birth Health & Heredity
基金
国家自然科学基金资助:30100037
