细胞毒性T细胞表位在人乳头瘤病毒疫苗研究中的意义及进展

Progress of CTL epitopes in the construct of human papilloma virus vaccine

人乳头瘤病毒(human papilloma virus,HPV)选择性感染皮肤或黏膜上皮细胞,局部形成增生性病变,甚至诱发恶性肿瘤,而以CTL为特征的细胞免疫对抑制HPV感染引起的机体损伤具至关重要的作用。在抗原结构和功能研究中,由CTL识别的抗原决定簇被确定,使含有CTL表位的疫苗取得了长足进展。

Human papilloma virus （HPV） has been demonstrated to be the most causative pathogen of CA （Condyloma acuminatum） and cervical cancer. HPVs have the property of strictly epithelial infection, high specificity of host and unable reproduction in routine cell culture, which restrict the research on the biological function and immunological mechanism. Since natural immune responses to persistent infection of HPV are unable to elicit a sufficient immune protection due to poor immunogenicity of HPV, up-regulation of immune responses is difficult to achieve. Thereafter, how to raise the immunological response to HPV to reduce the relapse rate of CA by host remains a focusing problem. Cytotoxic T lymphocytes （CTL） protect against viruses including HPV. Enhancement of presentation of the HPV antigen to elicit efficiently specific CFL response has been a research emphasis. This current study addresses elicitation of CFL against conserved HPV epitopes and the implications of our findings on future preventive HPV vaccine designs.