热休克蛋白27与P53在宫颈癌中的表达及临床意义

Expression and clinical significance of HSP27 and P53 in cervical squamous carcinomas

目的探讨热休克蛋白27(HSP27)在宫颈鳞癌发生、发展中的表达及其与抑癌基因P53蛋白表达的关系。方法应用免疫组化SP法观察80例宫颈鳞癌和30例宫颈上皮肉瘤样病变(CIN)组织中HSP27蛋白、P53的表达,并分析其相互关系。结果HSP27蛋白在宫颈鳞癌、CIN组织、正常宫颈组织的阳性表达率分别为69.5%、84.7%和10.0%,HSP27蛋白的表达与宫颈鳞癌病理分级和临床分期负相关(P<0.05),并与P53的表达呈正相关。结论HSP27参与宫颈鳞癌早期的发生发展,并与P53蛋白的表达密切相关。

Objective To study heat shock protein 27 （HSP27） expression in cervical squamous carcinomas and its correlation with the expression of P53 protein. Methods Immunohistochemical staining for HSP27 and P53 were performed with SP methods in 80 cases of cervical squamous carcinomas and 30 cases of cervical intraepithelial neoplasia （CIN）. Results The expression rate of HSP27 was 69.5% in cervical squamous carcinomas, 84.7% in CIN and 10.0% in normal cervical tissue respectively, and HSP27 expression was negatively correlated with the degree of differentiation and clinical stages of cervical squamous carcinomas （P〈0.05） but positively correlated with P53 expression. Conclusions HSP27 may be involved in the early period of pathogenesis and development of cervical squamous carcinomas and closely correlated with P53 expression.