期刊文献+

塞来昔布对非小细胞肺癌化疗的增敏作用及机制 被引量:4

The sensitizasion effects and its mechanism of celecoxib on chemotherapy in patients with non-small-cell lung cancer
下载PDF
导出
摘要 目的探讨塞来昔布对非小细胞肺癌(NSCLC)的化疗增敏作用及其机制。方法应用噻唑蓝比色法(MTT)检测顺铂(DDP)、足叶乙甙(VP16)单独应用及与塞来昔布联合应用的增殖抑制率,并根据金氏公式计算Q值,评价两药的合用效应。应用流式细胞术检测各处理组的凋亡率。结果DDP联合塞来昔布后对NSCLC抑制作用明显增强,二者合用有协同作用。VP16联合塞来昔布后对NSCLC抑制作用明显增强,二者合用有协同作用。塞来昔布与顺铂联合用药的凋亡率明显高于单用药组(P<0.01)。结论塞来昔布可增强DDP、VP16对NSCLC的增殖抑制作用,具有化疗增敏作用,其机制可能与塞来昔布促进凋亡有关。 Objective To investigate the sensitizasion effects and its mechanism of celecoxib in non-smallcell lung cancer (NSCLC). Methods The inhibitory rate on cell proliferation of NSCLC in celecoxib group, DDP group, VP16 group , DDP with celecoxib group and VP16 with celecoxib group was detected by MTT assay. The Q value was calculated to judge the sensitization effect. The apoptosis of cancer cells were detected by flow cytometry. Results The DDP with celecoxib and VP16 with celecoxib could increase the inhibitory effect on cell proliferation of NSCLC. The synergistic effect of the two drugs was found. The apoptotic rate in DDP with celecoxib group was higher than that in DDP group ( P 〈 0.01 ). Conclusion The celecoxib could increase the inhibitory effect of DDP and VP16 on cell proliferation of NSCLC and the sensitizasion effect in chemotherapy, which may related with cell apoptosis induced by celecoxib.
出处 《河北医药》 CAS 2006年第9期783-784,共2页 Hebei Medical Journal
关键词 塞来昔布 顺铂 足叶乙甙 化疗增敏 celecoxib DDP VP16 chemotherapy sensitizasion
  • 相关文献

参考文献6

二级参考文献17

  • 1Hida T, Kozaki K, Ito H, et al. Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents. Clin Cancer Res, 2002,8 (7) : 2443-2447.
  • 2Chang HC, Weng CF. Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. Oncol Rep,2001,8(6) : 1321-1325.
  • 3Pyo H, Choy H, Amorino GP, et al. A selective cyclooxygenase-2inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res,2001,7(10): 2998-3005.
  • 4Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.Adv Enzyme Regul,1984,22: 27 55.
  • 5Soriano AF, Helfrich B, Chan DC, et al. Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res, 1999, 59 (24) : 6178-6184.
  • 6Kolfschoten GM, Hulscher TM, Pinedo HM, et al. Drug resistance features and S-phase fraction as possible determinants for drug response in a panel of human ovarian cancer xenografts. Br J Cancer,2000,83(7) : 921-927.
  • 7Chevillard S, Pouillart P, Beldjord C, et al. Sequential assessment of multidrug resistance phenotype and measurement of S-phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy. Cancer,1996,77(2) : 292-300.
  • 8戴体俊.协同、拮抗等定义亟待统一[J]生理科学进展,1997(04).
  • 9江明性.药理学[M]人民卫生出版社,1989.
  • 10Peters GJ,Backus HH,Freemantle S,et al.Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism[].Biochimica et Biophysica Acta.2002

共引文献163

同被引文献61

引证文献4

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部