血管内皮生长因子-C的表达与宫颈癌生物学行为的关系

Correlation between the expression of VEGF-C and biological behavior in cervical carcinoma

目的研究VEGF-C表达与宫颈癌临床病理生物学行为的关系。方法免疫组化S-P法检测59例宫颈癌手术标本中VEGF-C蛋白表达情况。结果宫颈癌中VEGF-C蛋白表达率为66.1%(39/59),与盆腔淋巴结转移显著相关(P=0.005)。但与年龄、国际妇产科联盟(FI-GO)分期、组织学类型、组织学分级和肿瘤直径无关。VEGF-C表达阳性组5年生存率显著低于阴性组(P=0.006)。结论宫颈癌组织中VEGF-C蛋白表达与宫颈癌侵袭转移和预后有关,检测VEGF-C对了解宫颈癌生物学行为和评估预后具有一定的临床价值。

Objective To study the relationship between expression of vascular endothelial growth fac- tor - C and the clinicopathological behavior in uterine cervical cancers. Methods The expression of VEGF - C was identified by using immunohistochemical （SP） method in the 59 parafin specimens. Results Tile expres- sion rate of VEGF - C was 66.1% in uterine cervical cancers, and the expression of VEGF - C correlated with pelvic lymph node metastasis significantly （ P = 0. 005）. But no relationship was found with patients age, FIGO staging, histological types, histological grading and tumor size （P 〉 0.05）. The 5 - year survival rates of the patients in VEGF - C positive expression group was signifieantly lower than those in the negative expression group （P = 0. 006）. Conclusion The expression of VEGF- C in uterine cervical cancers was related to the invasion, metastasis and prognosis. Detection of VEGF - C may be helpful in further understanding the biologi- cal behavior and prognosis evaluation of cervical cancer.