吗啡联合赖氨匹林用于小儿术后静脉镇痛临床观察

Study of morphine combined aspirin-DL-lysine used in postoperative intravenous analgesia in children

目的:观察吗啡联合赖氨匹林用于小儿术后静脉镇痛的效果和不良反应。方法:60例腹部手术患儿随机分为两组,术后分别采用吗啡(M组)和吗啡联合赖氨匹林(M+L组)行静脉镇痛治疗,观察各组疼痛评分、镇静评分、HR、M AP、RR、SpO2、T和主要不良反应的发生率。结果:疼痛评分两组相似(P>0.05),镇静评分术后4h、12 h时两组相似(P>0.05),但24 h、36 h、48 h时M组高于M+L组(P<0.05),M组恶心、呕吐、皮肤瘙痒发生率高于M+L组(P<0.05)。结论:吗啡联合赖氨匹林用于小儿术后静脉镇痛效果确切,不良反应少于等效量吗啡。

Objective：To observe the efficacy and side effects of morphine combined aspirin-DL-lysine used in postoperative intravenous analgesia in children. Methods ：Sixty children undergone abdominal operation were randomly and equally divided into two groups,after operation which received intravenous analgesia treatment by morphine （group M ） and morphine combined aspirin-DL-lysine （group M ＋ L） respectively. The pain scores, sedation scores, HR,MAP,RR,SpO2,T and major side effects were observed. Results：The pain scores were similar in two groups（P 〉0. 05）. The sedation scores in group M were similar to those in group M＋L at postoperative 4 and 12 hours,but higher than those in group M＋L at postoperative 24,36 and 48 hours（P〈0. 05）. The side effects of nausea,vomiting and pruritus cutanea in group M were higher than those in group M＋L（P〈0. 05）. Conclusion：Morphine combined aspirin-DL-lysine was efficient used in postoperative intravenous analgesia in children,and its side effects were less than those of equivalent morphine.