芦荟大黄素体外抑制人舌癌及肺癌肿瘤细胞生长的初步研究

The Inhibitory Effects of Aloe-emodin on Tongue and Lung Cancer Cell Lines in Vitro

目的观察芦荟大黄素在体外对人舌癌细胞株Tca 8113及肺癌细胞株YTMLC肿瘤细胞的生长抑制作用.方法不同浓度的药物作用于培养的肿瘤细胞,应用MTT法和光学显微镜观察药物对细胞的生长抑制作用.结果随着药物作用浓度升高,细胞增殖随之下降,且该抑制作用具有一定的浓度-时间-效应关系,在芦荟大黄素浓度为10 mg/L时抑制作用最为显著.结论芦荟大黄素在体外可以对人舌癌细胞株Tca 8113和肺癌细胞株YTMLC肿瘤细胞产生生长抑制作用.

Objective To investigate the inhibitory effect of aloe - emodin on tongue and lung cancer cell lines Tca 8113 and YTMLC. Methods MTT assay and light - microscope were used to evaluate the inhibitory effect of aloe - emodin on the cancer cells. Results Along with the increasing concentration of the drug, the proliferation of the cells decreased. There are relations of concentration - time - effect between the drug and cells and the suppressing effect is most significant at the drug concentration of 10 μg/mL Conclusion Aloe - emodin can inhibit the growth of the tongue cancer cell line Tca 8113 and lung cancer cell line YTMLC in vitro.