孟鲁司特治疗变应性鼻炎的疗效观察

Investigation of the curative effects of singulair in allergic rhintis

目的观察孟鲁司特(顺尔宁)在变应性鼻炎中的疗效及治疗前后患者血清中嗜酸性粒细胞阳离子蛋白(ECP)的水平。方法以西替利嗪为阳性对照,比较两组治疗有效率,同时测定治疗前后患者血清ECP水平。结果西替利嗪组治疗有效率为93.3%,顺尔宁组治疗有效率为90.0%,两组之间无统计学差异。西替利嗪组治疗前后血清ECP水平无明显变化,而顺尔宁组治疗后ECP较治疗前极显著下降(P<0.01)。结论顺尔宁对于变应性鼻炎有较好疗效。

Objective Investigate the clinical effects of Singulair in allergic rhinitis patients, and detect the change of serum levels of eosinophil cationic protein （ECP）. Methods Using Cetirizine as positive control, compare the therapy effective rates of the two groups, and detect the serum levels of ECP of the two groups pre ＆ post therapy. Results The effective rates of the Cetirizine ＆ Singulair groups are 93.3% ＆ 90. 0% respectively, there is no statistics different between them. There is significant descent of ECP level in the Singulair group（P〈0. 01）, but not in the Cetirizine group. Conclusion Singulair is a effective drug to allergic rhinitis.