脑梗塞患者抗凝血酶-Ⅲ、血浆蛋白C活性水平测定及意义

Measurement and signific of antiprothrombin-Ⅲ and protein-C in patients with cerebral infarction

[目的]测定脑梗塞患者抗凝血酶-Ⅲ(AT-Ⅲ)、血浆蛋白C(PC)的活性水平并分析其意义。[方法]测定30例脑梗塞急性期和稳定期外周血浆中AT-Ⅲ、PC的活性水平。[结果]脑梗塞组急性期AT-Ⅲ、PC水平低于正常对照组(均为P<0.05);脑梗塞组稳定期外周血浆中AT-Ⅲ、PC活性水平与正常对照组无差异(均为P >0.05)。[结论]脑梗塞急性期存在AT-Ⅲ、PC活性水平降低现象,但难以成为脑梗塞发病的直接病因。

[Objective] To measure and analyse the level of antiprothrombin-Ⅲ （AT-Ⅲ ） and protein-C （PC） in cerebral infarction patients. [Methods] The peripheral plasma levels of AT- Ⅲ and PC were measured in 30 acute and stable cerebral infarction patients, and 30 healthy individuals talking sex-and age-matched as control. [Results] The peripheral plasma levels of AT- Ⅲ and PC in the acute phase of cerebral infarction were significantly lower than the healthy group （ P 〈 0.05）. The peripheral plasma levels of AT-Ⅲ and PC in the stable phase of cerebral infarction were not significantly difference with the healthy group （ P 〉 0.05）. [Conclusion] There is a reduction of the peripheral plasma levels of AT- Ⅲ and PC in acute phase of cerebral infarction, however, it is not the direct etiology of the cerebral infarction.