嗜麦芽窄食单胞菌体外药物敏感性研究

In vitro susceptibility of Stenotrophomonas maltophilia isolates to antimicrobial agents

目的比较10种抗菌药物(莫西沙星、加替沙星、左氧氟沙星、环丙沙星、头孢哌酮-舒巴坦、替卡西林一克拉维酸、哌拉西林-三唑巴坦、头孢吡肟、头孢他啶、复方磺胺甲噁唑)对临床分离嗜麦芽窄食单胞菌的体外抗菌活性。方法琼脂稀释法测定10种抗菌药物对来自北京3所医院的200株嗜麦芽窄食单胞菌的MIC值,用WHONET5．3软件进行药敏数据统计分析。结果200株菌对药物的敏感率排序为莫西沙星(84．5％)、加替沙星(79．5％)、左氧氟沙星(76％)、复方磺胺甲嗯唑(72．5％)、头孢哌酮-舒巴坦(41．5％)、替卡西林-克拉维酸(34％)、头孢他啶(23％)、环丙沙星(1 5％)、头孢吡肟(7％)和哌拉西林-三唑巴坦(4．5％)。结论新一代氟喹诺酮类药物如莫西沙星对嗜麦芽窄食单胞菌有较高的体外抗菌活性,是临床治疗嗜麦芽窄食单胞菌感染的较好选择。

Objective To compare the in vitro activity of moxifloxacin with other antimicrobial agents （gatifloxacin, levofloxacin, ciprofloxacin, ceftazidime, cefepime, cefoperazone-sulbactam, piperacillin-tazobactam, ticarcillin-clavulanic acid, trimethoprim-sulfamethoxazole） against the clinical isolates of Stenotrophornonas rnaltophilia. Methods The MICs of ten antimicrobial agents for 200 strains of S. rnaltophilia collected from three hospitals in Beijing were determined by two-fold agar dilution test. The data were analyzed by WHONET 5.3 software. Results The ranking of susceptibility rates from high to low was： moxifloxacin （84.5 % ）, gatifloxacin （79.5 % ）, levofloxacin （76 % ）, trimethoprim-sulfamethoxazole （72.5 %）, cefoperazonesulbactam （41.5%）, ticarcillin-clavulanic acid （34%）, ceftazidime （23%）, ciprofloxacin （15%） , cefepime （7%） and piperacillin-tazobactam （4.5 %）. New fluoroquinolones, such as moxifloxacin, have high in vitro activity against S. maltophilia. They may be good choice for the treatment of infections caused by S. rnaltophilia.