SHR与SD杂交大鼠血压与细胞内阳离子含量的关系

RELATIONSHIP OF CATIONS IN LYMPHOCYTES WITH BLOOD PRESSURE IN HYBRID SHR-SD RATS

观察ＳＨＲ与ＳＤ杂交大鼠血淋巴细胞内阳离子含量以及与血压的关系，拟阐明是否细胞膜阳离子转运异常是一种先天性遗传缺陷。结果显示，杂交大鼠淋巴细胞内Ｋ＋、Ｎａ＋、Ｍｇ２＋的含量与血压值并不相关，但淋巴细胞内Ｃａ２＋的含量与杂交大鼠的收缩压（ＳＢＰ）和舒张压（ＤＢＰ）呈明显正相关（ＳＢＰｒ＝０．５２，Ｐ＜０．０５；ＤＢＰｒ＝０．６２，Ｐ＜０．０１），血压增高的杂交大鼠（ＢＰ≥１７．３／１２．０ｋＰａ）细胞内Ｃａ２＋浓度（１．３±０．５ｆｍｏｌ／细胞）显著高于对照组（０．９±０．３ｆｍｏｌ／细胞，Ｐ＜０．０５）。提示，原发性高血压的发生与细胞膜存在特异性缺陷及遗传性离子转运障碍有关，而这一转运障碍的离子主要为Ｃａ２＋。

To elucidate whether the abnormalities in the cation transport system of the plasma membrane are genetically determined, the free cytosolic Na+, K+,Ca2+ and Mg2+ in lymphocytes from hybrid rats crossmated between spontaneously hypertensive rats(SHR)and Sprague Dawley (SD)rats have been measured,and the correlationship of the cations with the blood pressure in these hybrid rats has also been determined. In lymphocytes from hybrid rats,no correlation between cytosolic Na+, K+, Mg2+ and blood pressure was revealed. However, the cytosolic Ca2+ in lymphocytes was significantly correlated to the systolic (r= 0. 52, P<0. 05) and diastolic blood pressure ( r= 0. 62. P<0. 01) by linear regression analysis. In conclusion, the etiology and pathogenetic mechanism of hypertension are related to plasma membrane abnormality in ion transport, especially to Ca2+,which is determined genetically rather than environmentally.