极性交替直流电及其离子导入作用的实验研究

Experimental Study on Alternate Polarity DC and Its lonophoresis Effect

将大鼠和健康自愿者随机分为直流电组和极性交替直流电组,分别用不同电流强度和通电时间,观察大鼠皮肤PH值变化,皮肤损伤情况及~131I人体离子导入量的实验.结果表明:直流电组电流强度0.1mA/cm^2通电60min,PH值已明显变化并出现皮肤烧伤;而极性交替直流电组电流强度0.5 mA/cm^2通电40min以内,pH值无明显变化,电极下皮肤无烧伤.在人体离子导入量观察中,其耐受的电流强度、时间以及离子导人量均具有更大的优越性.并探讨了导人原理.对指导直流电的临床应用有重要意义.

The selected big mice and healthy volunteers, randomly divived into direct currect group (DC group) and alternate polarity CD group (APDC group), underwent ionophoresis of constant DC and APDC respectively under various electric current intensity with conducting duration. The pH values and damage degrees on the skin in mice and quantified electrophoresis of ^(131) I to human body were observed. The results showed that in constant DC group the noticeable changes of pH values on the mouse skin had been detected at the time of current intensity to 0.1 mA/cm^(2) and conducting duration 60 min and skin burning occurred. However , in APDC group no changes of pH values and skin burning were found at the time of current intensity to 0. 5 mA/cm^(2) and conducting duration 40 min. It was also observed that human body could tolerate stronger current intensity with longer conducting duration and more ionophoresis. The mechanism of ionophoresis were also explored, which played an important role for the clinical application of DC.