铜绿假单胞菌多重耐药指标的研究

Study on the markers of multi-resistance of Pseudomonas aeruginosa

目的研究铜绿假单胞菌（PA）多重耐药指标。方法应用美国BD公司的Phoenix100药敏条（MIC法）检测5组121株铜绿假单胞菌临床分离株的四大类七种抗菌药物的耐药性，以诊断效率评价其作为多重耐药指标的价值。结果本组121株菌，对七种抗菌药物（哌拉西林、庆大霉素、丁胺卡那霉素、复方新诺明、环丙沙星、头孢他啶、亚胺培南）的多重耐药指标的有效率分别为93．39％，90．91％，89．26％，87．60％，86．78％，55．37％，59．50％。结论哌拉西林、庆大霉素作为铜绿假单胞菌多重耐药指标的有效率均很高，哌拉西林最高，最适于作为铜绿假单胞菌多重耐药指标。

Objective To study the markers of multi-resistance of Pseudomonas aeruginosa. Methods To detect the susceptibility of 7 types of antimicrobiologics agents of-121 strains of PA isolates （5 groups） using MIC method （Products of BD company, USA）, evaluating the value of the 7 types of agents acting as the markers of multi-resistance Pseudomonas aeruginosa by diagnostic efficiency. Results In the 121 PA strains, the diagnostic efficiency of 7 types of antimicrobiologics agents Piperacillin, Gentamicin, Amikacin, Trimmethoprim/Sulfamethoxazole, Ciprofloxacin, Ceftazidime, Imipenem is 93.39%, 90.91%, 89.26%, 87.60%, 86.78%, 55.37%, 59.50% respectively, acting as the markers of multi-resistance Pseudomonas aeruginosa. Conclusion The diagnostic efficiency of Piperacillin and Gentamicin is high, Piperacillin is highest, the best marker acting as the markers of multi-resistance Pseudomonas aeruginosa.