摘要
目的提出中药指纹图谱多维多息特征数字化评价方法,用F和I等37个指标揭示中药指纹图谱的多维多息特征。方法用自行研制的“中药指纹图谱多维多息特征数字化评价系统软件”评价清热解毒注射液的11味药材、中间体和制剂的HPLC指纹图谱实验结果,进行比较研究。结果从积分信号强度、信号均化程度、分离度、指纹信息量等多方面综合评价出金银花、黄芩、连翘、中间体和制剂的指纹图谱比较理想。结论F和I等37个指标可客观、真实、全面地揭示中药指纹图谱的多维多息的数字化特征。
OBJECTIVE To establish the digital evaluation system of the multi-dimensional information characteristics of traditional Chinese medicine fingerprint, and to disclose the multi-dimensional information characteristics of traditional Chinese medicine fingerprint with 37 parameters such as F and I. METHODS The HPLC fingerprints of the Qingrejieduzhusheye and its ingredients were evaluated by the microsoft of the digital evaluation system of traditional Chinese medicine fingerprint. RESULTS As far as the peak signal intensity, the uniform of peak signal, resolution and the fingerprint information were concerned, the fingerprint of FLOS LONICERAE, RADIX SCUTELLARIAE, FRUCTUS FORSYTHIAE, intermediate and the injection was good. CONCLUSIONS The 37 parameters such as F and I can be used to objectively, authentically and thoroughly evaluate the multi-dimensional information characteristics in super traditional Chinese medicine fingerprint.
出处
《中南药学》
CAS
2006年第5期323-328,共6页
Central South Pharmacy
基金
国家自然科学基金重大研究计划项目(90612002)
关键词
中药指纹图谱
多维多息特征
数字化评价方法
清热解毒注射液
traditional Chinese medicine fingerprint
multi-dimensional information characteristics
digital evaluation system
Qingrejieduzhusheye
