摘要
【目的】观察体外循环()CPB手术前使用沐舒坦对急性肺损伤的保护作用,并探讨其机制。【方法】60例先天性心脏病患儿,随机分成三组:实验组(甲组,n=20)于CPB前30min静推沐舒坦30mg;对照Ⅰ组(乙组,n=20)于CPB后静脉推注沐舒坦30mg;对照Ⅱ组(丙组n=20)不用任何呼吸系统药物。分别于CPB前,CPB后3h测量肺泡-动脉氧分压差(A-aDO2),动脉血超氧化物歧化酶/丙二醛(SOD/MDA)值。【结果】实验组术后A-aDO2明显高于对照Ⅱ组(P<0.05),但与对照Ⅰ组相比差异无显著性(P>0.05)。实验组SOD水平明显高于对照Ⅱ组(P<0.05),MDA水平明显低于对照组。【结论】体外循环手术前静脉使用沐舒坦(30mg)可以减轻术后肺损伤。
[Objective]To study the protective effect and mechanism of Ambroxol against lung injury after cardiopulmonary bypass(CPB). [Methods]Sixty children with congenital heart disease were divided into three groups randomly: treating group ( groupA, n= 20), given ambroxol 30mg preopreatively ; control group 1 ( group B n =20)given ambroxol 30mg postoperatively; while the control group 2 given nothing. A-aDO2 was measured before CPB and 3h after CPB. SOD/MDA values in the artery were measured before and 3h after CPB. [Results]A-aDO2 value in the treating group was lower than in the control group 2; the SOD value was significantly higher, whereas MDA value was significantly lower in the treating group than those in the control group 2,3h after CPB. [Conclusion]Infusing ambroxol(30 mg) before CPB has protective effect on lung injury. The present study indicates that the protective effect may be related to the enhanced ability against lipid peroxidation.
出处
《医学临床研究》
CAS
2006年第10期1591-1593,共3页
Journal of Clinical Research
关键词
体外循环
肺/损伤
extracoporeal circulation
lung/IN