乙型肝炎合并丙肝患者血清sIL-2R水平的检测与分析

Clinical Significance of the Measurement of Soluble Interleukin-2 Receptor in Patient with Hepatitis B and C

【目的】了解乙型肝炎合并丙型肝炎患者血清可溶性白细胞介素2受体(sIL-2R)水平,探讨sIL-2R在病毒性肝炎发病中的作用。【方法】应用ELISA方法对23例乙型肝炎合并丙型肝炎患者,19例丙型肝炎患者,20例乙型肝炎患者、20例非活动期HBV携带者,20例正常对照组血清sIL-2R进行检测。【结果】乙肝合并丙肝患者sIL-2R含量(307.0±43.2)U/ml,单纯丙肝患者sIL-2R含量(264.1±35.1)U/ml,单纯乙肝患者sIL-2R含量(278.1±38.3)U/ml,三组均明显高于HBV携带组(221.3±25.1,P<0.05)及正常对照组(214.9±23.0,P<0.01),而三组之间相比并差异无显著性(P>0.05),HBV携带组与正常对照组相比无明显差异(P>0.05)。【结论】HCV合并HBV感染及单纯HCV、HBV感染时机体细胞免疫功能处于紊乱状态,sIL-2R可能在病毒性肝炎的发病过程中发挥重要作用,sIL-2R的测定可以作为判定肝组织损伤的指标之一。

[Objective]To study the change of serum concentrations of soluble interleukin-2 receptor （sIL- 2R） in patient with hepatitis B and C. [Methods]The sIL-2R levels in 23 patients with hepatitis C and B, 19 patients with hepatitis C,20 patients with hepatitis B virus carrier , 20 patients with hepatitis B virus and 20 healthy controls were analyzed by ELISA. [Results]The levels of serum sIL-2R in group of the hepatitis C and hepatitis B[（307.0±43.2） U/ml],and single C[（264. 1±35.1 ）U/ml）], single hepatitis B[（278.1±38.3 U/ml）]were significantly higher than those in the group hepatitis B virus carrier （ P〈0.05）, and in healthy controls[（214.9± 23.0 ）U/ml]（ P〈0.01, respectively）. And there was no significant difference among three groups （ P〉0.05）. [Conclusions] HBV and HCV infection may cause the disorder of cell immune function, the change of sIL-2R level is considered of clinical value to estimate the damage of liver, and sIL-2R may participate in the pathogenesis of liver damage in chronic HBV and HCV infection.