动态光谱法对提高近红外无创血液成份检测精度的理论分析

THEORETIC STUDY ON IMPROVING NONINVASIVE MEASUREMENT ACCURACY OF BLOOD COMPONENT BY DYNAMIC SPECTRUM METHOD

近红外光谱无创血液成分检测因测量方法具有优越性,已经成为生物医学领域的研究热点之一.但除血氧以外,目前还没有进入临床应用的报道,其原因在于个体差异和测量条件对检测精度的影响.研究了一种不同于传统的新检测方法-动态光谱法可使测量精度提高.先从检测原理出发,研究了传统的近红外无创血液成分测量过程中产生误差、造成测量精度较低的因素;再分析了动态光谱法对这些因素的抑制或克服.从理论上得到了动态光谱法可以大大提高血液成分无创检测精度的结论,为基于光谱法的无创血液成分检测的临床应用提供了条件.

Utilizing near-infrared spectroscopy for non-invasive blood component concentration sensing has been a focusing topic in biomedical optics applications. But, there is no report about any successful detection techniques that can satisfy the requirements of clinic application （except the blood oxygen）. One of the most important difficulties is the effect of the individual discrepancy. Dynamic spectrum （DS） is a new detecting method for blood spectrum developed in recent years. The improvement of accuracy by DS was studied compared with the traditional way here. The errors of traditional NIR non-invasive blood component concentration decision were studied based on the measure theory. Then the way of eliminating these errors by DS was analysed. Our conclusion is that the DS method can improve the accuracy of non-invasive blood component concentration measuring.