摘要
目的 研究头孢拉定对黄芩苷在大鼠体内药动学的影响.方法 用HPLC-ECD方法测定头孢拉定和黄芩苷合并给药组与黄芩苷单独给药组黄芩苷在大鼠体内的血药浓度,比较两者的药动学参数.结果 头孢拉定和黄芩苷合并给药组黄芩苷Cmax为（782.63±469.37）ng/mL,AUCo～24 h为（8 407.86±3 476.14）ng/mL·h；黄芩苷单独给药组黄芩苷Cmax为（2 645.62±601.42）ng/mL,AUC0～24h为（28 952.90±5 731.42）ng/mL·h.结论 两者药动学参数存在显著性差异（P＜0.05）,口服头孢拉定严重降低了黄芩苷的血药浓度.提示临床应合理用药.
Objective To study the effect of oral Cefradine on pharmacokinetics of baicalin in rats in vivo. Methods The rats were divided into two groups： one was supplied with baicalin individually and the other was supplied with the combination of Cefradine and baicalin. Plasma concentrations of two groups were detected by HPLC with electrochemical detection （ECD）. The pharmacokinetic parameters were calculated by statistical analysis and compared. Results The pharmacokinetic parameters of combination administration group were Cmax（782.63±469.37） ng/mL, AUC0-24h（8 407. 86±3 476. 14） ng/mL· h; while the individual administration group of baicalin was Cmax （2 645. 62 ± 601. 42） ng/mL, AUC0-24h （28 952.90± 5 731.42） ng/mL · h. Conclusion The main pharmacokinetic parameters show significant difference between the two groups （P 〈 0.05）. Taking Cefradine orally influences the plasma concentration of baicalin within an ideal range.
出处
《中草药》
CAS
CSCD
北大核心
2006年第10期1530-1532,共3页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(30171139)
