心肌尔康对柯萨奇B_（3m）株的抑制作用

Effects of Xinjierkang as inhibitor of coxsackie B_(3m) virus infection in vitro

用细胞病变抑制试验研究心肌尔康抗柯萨奇Ｂ３ｍ的体外作用。发现心肌尔康作１０倍系列稀释试验时，对１和１０ＴＣＩＤ５０病毒的５０％抑制（ＩＣ５０）剂量分别为１．３４×１０－２ｇ·Ｌ－１和１．５４ｇ·Ｌ－１，对１００和１０００ＴＣＩＤ５０病毒不能测出ＩＣ５０；该药在２倍系列稀释时，对１０和１００ＴＣＩＤ５０病毒的ＩＣ５０分别为１．８１ｇ·Ｌ－１和２．５８·Ｌ－１，对１０００ＴＣＩＤ５０病毒仍无抑制，试验表明，心肌尔康在体外对柯萨奇Ｂ３ｍ病毒有一定的抑制作用。

Xin-ji-er-kang is a compound chinese herbs proved to have certain clinical effects on myocarditis. It is observed to have anti-coxsackie virus B_3m effects in HeLa cell line by cytopathic-inhibiting-test. Its IC_50 to 1 and TCID_50 viruses is 1. 34 ×10￣-2 g · L￣-1 and 1. 54 g · L￣-1 when diluted by 10fold series and to 10 and 100 TCID_50 viruses 1. 81 g · L￣-1 and 2. 5 g · L￣-1 respectively when diluted by 2-fold series. However, it can not inhibit 1000 TCID_50 viruses, which suggests xin-ji-er-kang inhibits coxsackie virus B_3m strain to a certain degree in vitro.