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壳聚糖微球作为口服疫苗载体的应用 被引量：2

The application of chitosan microspheres as the potential carrier for oral vaccine delivery
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摘要 壳聚糖是一种被广泛应用的天然聚合物,其特殊的物理化学性质和生物特性为口服疫苗微球载体的研究提供了一条新途径,壳聚糖在口服疫苗呈递中有广阔的应用前景。此文就壳聚糖微球作为口服疫苗载体的应用进行综述。
作者 李正艳 何应
机构地区 天津大学药物科学与技术学院
出处 《中国生化药物杂志》 CAS CSCD 2006年第5期313-315,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 壳聚糖 微球 口服疫苗
分类号 Q538 [生物学—生物化学] R943 [医药卫生—药剂学]
  • 相关文献

参考文献20

  • 1Diwan M,Park T G.Pegylation enhances protein stability during encapsulation in PLGA microspheres[J].J Control Release,2001,73(2-3):233-244.
  • 2Kang J,Schwendeman S P.Comparison of the effects of Mg(OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectalble poly(d,l-lactide-co-glycolide) implants[J].Biomaterials,2002,23(1):239-245.
  • 3Van der Lubben I M,Verhoef J C,van Aelst A C,et al.Chitosan microparticles for oral vaccination:preparation,characterization and preliminary in vivo up take studies in murine Peyer's patches[J].Biomaterials,2001,22(7):687-694.
  • 4Van der Lubben I M,Kersten G,Fretz M M,et al.Chitosan microparticles for mucosal vaccination against diphtheria:oral and nasal efficacy studies in mice[J].Vaccine,2003,21(13-14):1400-1408
  • 5Roy K,Mao H Q,Huang S K,et al.Oral gene delivery with chitosan DNA nanop particles generates immunologic protection in a murine model of peanut allergy[J].Nature Med,1999,5(4):387-391.
  • 6Chew J L,Wolfowicz C B,Mao H Q,et al.Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen,Der p1 for oral vaccination in mice[J].Vaccine,2003,21(21-22):2720-2729.
  • 7Kunisawa J,Okudaira A,Tsutsumi Y,et al.Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses[J].Vaccine,2001,19:589-594.
  • 8曹俊,周南进.壳聚糖抗肿瘤作用的研究进展[J].中国生化药物杂志,2005,26(2):126-127. 被引量：25
  • 9Seferian P G,Martinez M L.Imune stimulating activity of two new chitosan containing adjuvant formulations[J].Vaccine,2001,19(6):661 -668.
  • 10Murata Y,Toniwa S,Miyamoto E,et al.Preparation of alginate gel beads containing chitosan salt and their function[J].Int J Pharm,1999,176(2):265-268.

二级参考文献74

  • 1唐治华.脂质体作为细胞因子载体的研究进展[J].国外医学（免疫学分册）,1994,17(2):90-92. 被引量：4
  • 2陈慰浙,余心如.胶体金－胰岛素探针的制备与鉴定[J].浙江医科大学学报,1995,24(3):109-112. 被引量：2
  • 3王秀问,张宝珠.NIDDM微白蛋白尿患者血清胰岛素水平[J].临床荟萃,1996,11(16):732-733. 被引量：1
  • 4沈江波 林建立 张世馥.壳聚糖对人子宫颈癌HeLa细胞生长作用的研究.解剖学报,1997,28(4):421-421.
  • 5Bernkop-Sehnurch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems [ J ]. Int J Pharm ,2000,194( 1 ) :1 - 13.
  • 6严俊，化学通报，1984年，26页
  • 7Felt O, Buri P, Gumy R. Chitosan: a unique polysaccharide for drug delivery [ J]. Drug Dev Ind Pharm, 1998,24( 11 ) :979-993.
  • 8Felt O, Furrer P, Mayer JM, et al. Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention[J]. Int J Pharm, 1999,180 (2): 185-193.
  • 9Ohya Y, Takei T, Kobayashi H, et al. Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition[J]. J Microencapsul, 1993,10( 1 ): 1-9.
  • 10Mi FL, Wu YB, Shyu SS, et al. Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery [J]. J Biomed Mater Res,2002,59(3) :438-449.

共引文献82

同被引文献35

  • 1张立强,陶安进,石凯,寸冬梅,崔福德,郑俊民.肠溶包衣胰岛素-壳聚糖复合物纳米粒的制备及体内外性质[J].沈阳药科大学学报,2006,23(2):65-69. 被引量：15
  • 2应国清,卢霞,石陆娥,易喻,梅建风.新型胺基壳聚糖微球的制备及对黄酮类物质的吸附性能[J].中国生化药物杂志,2007,28(2):94-97. 被引量：10
  • 3Kompella U B, Lee V H. Delivery systems for penetration enhance- ment of peptide and protein drugs : design considerations [ J ]. Adv Drug Deliv Rev ,2001,46:211-245.
  • 4Prego C,Torres D,Alonso M J. The potential of chitosan for the o- ral administration of peptides [ J ]. Expert Opin Drug Deliv,2005,2 (5) :843-854.
  • 5Baldrick P. The safety of chitosan as a pharmaceutical excipient [ J ]. Regul Toxicol Pharmacol,2010 ,56 :290-299.
  • 6Tapola N S, Lyyra M L, Kolehmainen R M, et al. Safety aspects and cholesterol-lowering efficacy of chitosan tablets [ J ]. Am Coil Nutr, 2008,27 ( 1 ) :22-30.
  • 7Werle M, Takeuchi H, Bernkop S A. Modified chitosans for oral drug delivery[J]. Pharm Sci ,2009,98 ( 5 ) : 1643-1656.
  • 8Lankalapalli S, Kolapalli V R. Polyelectrolyte complexes: A review of their applicability in drug delivery technology [ J ]. Indian J Pharm Sci,2009,71:481-487.
  • 9Hamman J H. Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems[ J]. Mar Druss,2010,8 :1305-1322.
  • 10Sarmento B, Ribeiro A, Veiga F, et al. Alginate/Chitosan nanopar- ticles are effective for oral insulin delivery[ J]. Pharm Sei ,2007,24 (12) :2198-2206.

引证文献2

二级引证文献4

中国生化药物杂志
2006年 第5期

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