人乳头瘤病毒疫苗

Human papilloma virus vaccines

生殖道人乳头瘤病毒感染被认为是最普遍的性传播疾病。人乳头瘤病毒的状况能够预测鳞状上皮内病变将来的进展,高危型人乳头瘤病毒与肛门及生殖器区域的癌前病变及恶性病变有关。持续人乳头瘤病毒感染是宫颈上皮癌变的重要危险因子。预防性疫苗旨在增强免疫应答,以预防感染和防止临床疾病的发展。治疗性疫苗适用于已经出现人乳头瘤病毒感染的个体。发展中国家通过安全有效的疫苗来预防宫颈癌会得到的巨大受益,儿科给药也许是较好的解决方式。

Genital HPV infections are considered the most common sexually transmitted disease. HPV infection status predicts future progression of human squamous intraepithelial lesions （HSIL） , and high-risk types of HPV are associated with precancerous and malignant lesions in anogenital region. Persistent HPV infection is a critical risk factor. The preventive vaccine aims to increase an immune response so as to limit or prevent infection and block clinical progression of the disease. While the therapeutic vaccine is suitable for those individuals in whom HPV infection has already occurred. In the developing countries, the people may benefit from of such safe and effective vaccines to prevent cervical cancer. Maybe, childhood vaccination is a better solution for the disease.