摘要
目的:观察田七注射液延缓慢性肾功能衰竭(CRF下称“慢肾衰”)肾纤维化的临床疗效,并探讨作用机制。方法:将70例慢肾衰患者随机分为治疗组和对照组各35例,分别给予田七注射液和肾安注射液治疗,1个月为1疗程。观察治疗前后症状积分、血清层粘连蛋白、IV型胶原、肾功能、血脂、内皮素、白介素-8、不良反应。结果:治疗组总有效率71.43%,对照组总有效率48.57%,两组疗效相比差异有显著性(P<0.05);治疗组临床症状、纤维化、肾功能、脂质代谢明显改善(P<0.01或P<0.05),并优于对照组(P<0.01或P<0.05);内皮素、白介素-8显著降低(P<0.01);未发现不良反应。提示:田七注射液能延缓CRF肾纤维化进程,其机制可能调节脂质代谢和降低内皮素、白介素-8有关。
Objective To obseve the clinical effects of "Tianqi Injection" in retarding renal fibrosis of chronic renal failure (CRF) and its possible mechanism. Methods: 70 patients with CRF were randomized into two groups: treatment group in 35 cases were treated by Tanqi Injection and control group in which 35 cases treated by SenAn Injection, the therapeutic period is a month. Symptom score, Laminin, Collegen Ⅳ, renal function, blood lipid, endotheliolysin, interleukin - 8, side effects were measured before and after treatment. Results: The total effective rate was 71.43% in treatment group and 48.57% in control group, by contrasting the two groups there was a remarkable discrepancy (P 〈 0.01); Clinical Symptom, renal fibrosis, renal function, blood lipid, improved obviously in corttrol group (P 〈 0.05 or P 〈 0.01), and has marked curative effect in contrast with control group (P 〈 0.05 or P 〈 0.01), endotheliolysin and interleukin - 8 decreaded obviously (P 〈 0.01), no side effects were found. Conclusion: It is revealed that Tianqi Injection can retard renal fibrosiss of chronic renalfailre by adjusting blood lipid and decreading endotheliolysin and interleukin - 8.
出处
《辽宁中医杂志》
CAS
北大核心
2006年第10期1277-1279,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
广西科技资助项目(桂科攻9920021)