幽门螺杆菌清除治疗对反流性食管炎疗效的影响

Effect of Eradication Therapy for Helicobacter Pylori on Reflux Esophagitis

目的探讨幽门螺杆菌(Hp)清除治疗对反流性食管炎(RE)疗效的影响。方法将已确诊的58例Hp阳性的RE病人随机分为两组。其中观察组30例,对照组28例。两组病人均给予口服质子泵抑制剂和对症治疗,观察组在治疗的同时加用克拉霉素和阿莫西林作Hp抗菌治疗,对照组则不作Hp抗菌治疗。总疗程均为4周。疗程结束后比较两组病人的症状、胃镜下黏膜损害的改善程度。结果两组病人的症状改善程度差异无显著性,胃镜下黏膜损害改善程度差异亦无显著性。结论清除Hp与否对于RE病人,无论是临床症状的控制,还是黏膜损害性病变的改善并不产生显著影响。

Objective To investigate the effect of eradication therapy for helicobacter pylofi on reflux esophagitis. Methods Fifty- eight patients with reflux esophagitis accompanied by Helicobacter pylori were randomly divided into two groups,30 cases in observation group and 28 cases in control group. H（＋ ） - pump inhibitor were administrated in two groups for 4 weeks, in addition, eradication therapy by clarithromycin and amoxicillin for helicobacter pylori in observation group, not in control group. After that, the improvement degree of symptoms and mucosa - damage in gastroscope was compared between two groups. Results The effective rate of heart.bum , swallowing pain , retrostemal pain and dysphagia in two groups was 85.7% ,89.3% ,75.0% ,82.1% vs 82.1% ,89.3%, 82.1%, 85.7 % and that of mucosa - damage in gastroscope was 89.28% vs 85.71%. Conclusion The eradication therapy for helicobacter pylori on reflux esophagitis has no significant effect in improvement of symptoms and mucosa - damage in gastroscope.