乌司他丁对老年人工髋关节置换术患者围术期肝肾功能的影响

The effects of ulinastatin on liver and kidney functions in the aged patients with hip replacement operation at perioperative period

目的观察围术期应用乌司他丁(UT I)对老年人工髋关节置换术患者肝肾功能的影响。方法48例年龄≥65岁患者随机分为两组各24例,乌司他丁组(U组)术前1天至术后1、2、3天每8小时静脉滴注UT I10万单位,每天30万单位,术中不间断;对照组(C组)常规补液。检测两组术前1天、术后第1、3、7天谷丙转氨酶(ALT)、血尿素氮(BUN)、血肌酐(Scr)、尿γ-谷氨酰转肽酶(-γGPT)、N-乙酰氨基葡萄糖苷酶(NAG)及尿K/N a值。结果术后U组ALT低于C组(P<0.05),U组BUN、Scr、尿K/N a、尿-γGPT、NAG明显低于C组(P<0.05)。结论乌司他丁对老年人工髋关节置换术患者围术期肝肾功能有明显的保护作用。

Objective To observe the effects of ulinastatin （UTI） on liver and kidfiey functions in the patients（≥65 years old） with hip replacement operation at perioperative period. Methods 48 patients were randomly divided into two groups,the control group and the U group. The patients in U group were administrated by 30×10^4U UTI per day, 10× 10^4U per 8 hour,in one day before operation and 1st, 2nd, 3rd day after operation. The alanine amino transaminase （ALT）, blood urea nitrogen （BUN）, blood creatinine （Cr） ,urine glutamyl transpeptidase （γ-GTP） ,acetyglucosaminidasel （NAG） ,urine K＋/Na＋ration were detected one day before operation and lst,3rd,7th days after operation. Results Compared with the control group the level of ALT in UTI group was significantly decreasing（P〈0. 05） as well as BUN, urine K^＋/Na^＋, urine γ-GTP and NAG. Conclusion UTI can protect the liver and kidney function of the aged patient with hip replacement operation.