马兜铃酸I药动学研究进展

Advances in studies on pharmacokinetics of aristolochic acid I

马兜铃酸I在体内吸收迅速,分布迅速,大多数实验表明其体内分布呈一室模型,少量实验呈二室模型,马兜铃酸I的消除与其给药剂量有关,低剂量组消除较快,高剂量组消除较慢。马兜铃酸I药动学特征可能决定了其蓄积毒性的产生。

Aristolochic acid Ⅰ（AA-Ⅰ） was absorbed and distributed quickly in vivo,the plasma concentration-time curve were fit with the open two-compartment model and one - compartment model, respectively. The elimination of AA-Ⅰ has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-Ⅰ induce the cumulation of AA-Ⅰ in vivo and the nephrotoxin to the kidney and other viscera.