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心肌肥厚:calcineurin-NFAT通路可能是新的治疗靶点 被引量:3

Hypertrophy of the heart: calcineurin-NFAT pathway may be a new therapeutic target
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出处 《药学学报》 CAS CSCD 北大核心 2006年第10期913-916,共4页 Acta Pharmaceutica Sinica
关键词 calcineurin-NFAT通路 心肌肥厚 病理性心肌重构 calcineurin-NFAT signaling pathway cardiomyocyte hypertrophy pathological remodeling of the heart
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参考文献31

  • 1Levy ID,Garrison RJ,Savage DD,et al.Prognostic implications of echocardiographically determined left ventriculai mass in the Framingham heart study[J].N Engl J Med,1990,322:1561-1566.
  • 2Rossow CF,Minami E,Chase EG,et al.NFATc3-induced reductions in voltage-gated K^+ currents after myocardial infarction[J].Circ Res,2004,94:1340 -1350.
  • 3Huang B,Qin D,EI-Sherif N.Early down-regulation of K^+ channel genes and currents in the postinfarction heart[J].J Cardiovasc Electrophysiol,2000,11:1252 -1261.
  • 4Akhter SA,Luttrell LM,Rockman HA,et al.Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy[J].Science,1998,280:574-577.
  • 5van Rooij E,Doevendans PA,Crijns HJ,et al.MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction[J].Circ Res,2004,94:e18 -26.
  • 6Esposito G,Rapacciuolo A,Naga Prasad Sv,et al.Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress[J].Circulation,2002,105:85-92.
  • 7Hill JA,Rothermel B,Yoo KD,et al.Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy:preservation of systolic function[J].J Biol Chem,2002,277:10251-10255.
  • 8Booz GW.Putting the brakes on cardiac hypertrophy:exploiting the NO-cGMP counter-regulatory system[J].Hypertension,2005,45:341-346.
  • 9Wilkins BJ,Molkentin JD.Calcineurin and cardiac hypertrophy:where have we been? Where are we going?[J].J physiol,2002,541:1 -8.
  • 10Frey N,Katus HA,Olson EN,et al.Hypertrophy of the heart:a new therapeutic target[J].Circulation,2004,109:1580-1589.

二级参考文献23

  • 1张英俊,郭扬,贾庆中,王永利,张海林.双苯氟嗪抗大鼠全脑缺血再灌注所致海马CA1区神经元损伤的作用机制(英文)[J].药学学报,2005,40(2):97-104. 被引量:7
  • 2Jin K, Graham SH, Mao X, et al. Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global ischemia [ J ]. J Cereb Blood Flow Metab ,2001,21(12) :1411 - 1421.
  • 3Liu S, Khemlani LS, Shapiro RA, et al. Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia [ J ]. Infect Immun, 1998,66 ( 11 ): 5089 -5098.
  • 4Asai A, Qiu J, Narita Y, et al. High level calcineurin activity predisposes neuronal cells to apoptosis [ J ]. J Biol Chem, 1999,274 (48): 34450 - 34458.
  • 5Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-kappaB activity [J]. Annu Rev Immunol, 2000,18:621 - 663.
  • 6Mattson MP, Culmsee C, Yu Z, et al. Roles of nuclear factor kappaB in neuronal survival and plasticity [ J ]. J Neurochem, 2000,74 (2) :443 - 456.
  • 7Koulich E, Nguyen T, Johnson K, et al. NF-kappa B is involved in the survival of cerebellar granule neurons:association of I kappa B beta phosphorylation with cell survival [J]. J Neurochem, 2001,76(4) :1188 - 1198.
  • 8Jarosinski KW, Whitney LW, Massa PT. Specific deficiency in nuclear factor-kappa B activation in neurons of the central nervous system [J]. Lab Invest, 2001,81(9) :1275 - 1288.
  • 9Wood AM, Bristow DR. N-Methyl-D-aspartate receptor desensitisation is neuroprotective by inhibiting glutamateinduced apoptotic-like death [ J ]. J Neurochem, 1998,70(2) :677 -687.
  • 10MacDermott AB, Mayer ML, Westbrook GL, et al.NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons [ J ].Nature, 1986,321 (6069) :519 - 522.

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