2型糖尿病及其慢性并发症患者血清糖基化终末产物和一氧化氮水平及其相关性

The Correlation Between Serum Advanced Glycation End Products and Nitric Oxide Levels in Type 2 Diabetes and Chronic Complications of Diabetes

目的探讨糖基化终末产物和一氧化氮在2型糖尿病及其慢性并发症中的作用和相关性。方法用流动注射分析技术和分光光度法分别测定患者血清中糖基化终末产物和一氧化氮的含量,并与正常对照组进行比较。结果各患者组血清中糖基化终末产物水平均显著高于正常对照组,一氧化氮水平均明显低于正常对照组(P均<0.01)。结论血清糖基化终末产物水平的升高是糖尿病、糖尿病慢性并发症及心、脑血管疾病的重要原因之一,一氧化氮水平的减少可能是血管功能障碍和动脉粥样硬化的原因之一,血清糖基化终末产物水平的升高可能不是一氧化氮水平降低的独立影响因素。

Aim To study the effect of advanced glycation end prnducts （AGE） and nitric oxide （NO） ontype 2 diabetes and chronic complications of diabetes, and the correlation between AGE and NO. Methods The levels of serum AGE and NO were detected by flow injection assay and spectrophotometry. Results The level of serum AGE in all patient groups was significandy higher than that in control group, and the NO level was significantly lower than that in control group （ all P 〈 0.01）. Conclusion The increase of serum AGE played an important role in mediating the formation of diabetes, chronic complications of diabetes, cardiovascular and cerebrovascular diseases, and the reduction of serum NO level was probably one of reasons which resulted in vascular disfunction and atherosclerosis. The increase of serum AGE may not be an independent influential factor for the reduction of serum NO.