心导管插入术期间患者血脂和载脂蛋白的变化

The Changes of Serum Lipid and Apolipoprotein Concentrations during Cardiac Catheterization

目的探讨心导管插入行冠状动脉造影术、冠状动脉球囊扩张术和冠状动脉支架置入术对血脂及载脂蛋白测定值的影响。方法分别测定心导管插入前后119名患者(男性77名、女性42名)的血脂和载脂蛋白浓度。结果血脂和载脂蛋白浓度在心导管插入前后发生较大改变,插管后总胆固醇、甘油三酯、低密度脂蛋白胆固醇和载脂蛋白B分别下降了10.1%、30.7%、13.5%和19.1%,且冠状动脉球囊扩张和支架置入患者比单纯造影患者下降更显著。而高密度脂蛋白胆固醇和载脂蛋白A1插管前后的变化无统计学意义。结论心导管插入前后血脂和载脂蛋白检测结果相差较大,这种差异与肝素有关。

Aim Analysis on lipoprotein and apolipoprotein measuremem changes caused by coronary angiography （CAG）, percutaneous transluminal coronary angioplasty（FIEA）, and coronary stem inplantafion（PTCA＋ STENT）. Methods We have measured serum lipid and apohpoprotein concentrations against 119 patients （77 males and 42 females）before and after catheterization. Results Significant hpoprotein and apolipoprotein concentration changes were observed before cardiac catheterization vs. after cardiac catheterization. After cardiac catheterization, the average values of TC, TG, LDL-C, and apolipoprotein-B decreased by 10.1%, 30.7%, 13.5%, and 19.1% respectively, and obvious decreases in FIEA and STENT groups when compared to CAG group. However, changes in HDL-C and apolipoprotein A1 were not significant. Conclusions It was observed that heparin has more influence on the apolipoprotein in the blood rneasuremem results; there seems to be a positive correlation between the dosage of heparin and the rneasuremem result. In order to get the actual base data, it is highly recommended that we examine the lipoprotein and apolipoprotein data before conducting any CAG, PTCA,or PTCA＋STENT surgeries.