阿司匹林在双模型介孔分子筛组装过程中的缓释机理

SUSTAINED RELEASE OF A DRUG CARRIER SYSTEM ASPIRIN/BIMODAL MESOPOROUS MATERIALS

在本实验中，制备了双模型介孔分子筛，然后用三氨基三乙氧基硅烷（APTES）对双模型介孔分子筛进行改性，使分子筛孔道内表面上的羟基被氨基取代，从而作为阿司匹林的运输载体。结果表明，由于氨基取代量的不同，改性后的分子筛的载药量有所不同。同时考察了装载阿司匹林的分子筛组装体在水溶液中的药物释放率。

In this experiment, the bimodal mesoporous molecular sieves （BMMS） were synthesized, which were used as a aspirin-delivery vector by modifying their surface with arninopropyl groups. It is shown that the ratio of surface silanol groups and amino groups led to different drug loaded. Meantime, the rate of sustained release of the drug carrier in water was investigated.