^(99m)Tc-葡糖二酸显像剂的研究进展

The advanced in ^(99m)Tc labeled glucaric acid

葡糖二酸(GLA)是一种六碳二元羧酸盐的葡萄糖类似物,是葡萄糖在生物体内代谢的产物之一,存在于组织和体液中,可被99mTc标记。本文论述了GLA的制备、99mTc-GLA药盒的制备以及99mTc-GLA在心肌梗死显像和肿瘤显像中的研究进展。现有的研究结果表明,99mTc-GLA在诊断心肌梗死和某些肿瘤(如乳腺癌)表现了良好的性质,因此是一种很有应用前景和研究价值的显像剂。

Glucaric acid （GLA） is a six-carbon dicarboxylic acid sugar, one of the natural endogenous end-eatabolite of glueose, whieh is normally present in tissues and body fluids. It ean be labeled with ^99mTc. In this review we diseuss the synthesis of GLA and the investigation of ^99mTc-GLA inelude the preparation of the kit, myocardiol infarction imaging and some tumor imaging （espeeially in breast tumor imaging）. All the researches suggest that ^99mTc-GLA is a potential imaging for myocardiol infarction imaging and tumor imaging.