摘要
阿尔茨海默病(AD)是一种退行性神经功能障碍性疾病,其典型病理学特征是β-淀粉样蛋白斑块、神经纤维缠结和基底前脑乙酰胆碱能损害。PET分子探针,特别是靶向β-淀粉样蛋白斑块、乙酰胆碱酯酶或受体显像的分子探针是最可靠的AD早期检测手段之一。
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. The characteristic pathological lesions are deposits of β-amyloid plaques and neurofibrillary tangles after postmortem examination, and degeneration of cholinergic neurons of the basal forebrain. The positron emission tomography (PET) molecular probes targeting at β-amyloid plaques or acetylchergic is one of the most reliable tools for AD early detection.
出处
《国际放射医学核医学杂志》
2006年第4期202-205,共4页
International Journal of Radiation Medicine and Nuclear Medicine
基金
中国科学院知识创新工程重大项目(KJCXI-SW-08)
上海市自然科学基金项目(02ZB14061)