^(32)P-胶体灌注治疗慢性上颌窦炎动物模型的实验研究

The experimental study of ^(32)P-colloid perfusion therapy in the animal-models of chronic maxillary sinusitis

目的探讨32P-胶体灌注治疗慢性上颌窦炎动物模型的作用机制及治疗效果。方法选择雄性绵羊慢性上颌窦炎动物模型24只,采取上颌窦前外侧壁开窗术,按不同剂量分组将32P-胶体注入动物模型上颌窦腔内,注药后定期观察窦内细菌变化和黏膜的组织学变化,以体征、细菌培养、病理检查等项指标判定治疗效果。结果32P-胶体灌注治疗后,窦腔内菌种及慢性炎性细胞数量消失或明显减少,纤毛上皮结构基本完好。灌注治疗6个月后,治愈率达到83．3％,各组间比较具有非常显著性差异。结论实验证明了32P-胶体的抑菌作用和促进慢性炎症消退的作用,并确定了32P-胶体窦内用药的适宜剂量。放射生物学分布监测显示,对其他重要组织器官无任何影响。

Objective To search for the mechanism of ^32P-colloid perfusion therapy in the animalmodels of chronic maxillary sinusitis. Methods ^32P-colloid were injected into the male sheep maxillary sinuses of the animal-models of chronic maxillary sinusitis in different dosage group. The changes of bacteria and mucosael pathomorphology were observed by periodic germicuhure and pathology in 1, 3, 6 months after injection. Results After ^32P-colloid perfusion therapy, the amounts of bacterial species and chronic phlogistic cells were remarkable reduced, and the structure of cilia cells did not change. The curable rate was 83.3% in 6 months. There were remarkable difference in groups. Conclusions ^32P-colloid was provided with antibiosis and ruducing chronic phlogistic responses. We had found the optimal dose of ^32P-colloid perfusion in the maxillary sinuses through the study. The curable rate of single dose of ^32p-colloid perfusion in the maxillary sinuses was higher than other therapy, ^32p-colloid perfusion was simple and convenient. There was high selectivity of ^32p in the target organ, when there was no effect on other important organs through radiobiological measurement.