PET预测及评价肿瘤疗效的新进展

The new advance of prediction and evaluation of tumor therapeutic effects by PET

临床上评价及预测肿瘤疗效的手段很多,包括体格检查、普通影像学检查(X线摄片、CT、MRI等)和肿瘤标志物检测等,但这些方法均有很大的局限性,如主观性强、敏感性差等。PET可以早期准确地反映肿瘤相关生物特征,如血管生成、凋亡、乏氧和增殖等。因此,利用相应的可反映上述生物特征的显像剂行PET,可对肿瘤进行早期诊断、评价和预测肿瘤治疗的疗效,协助临床医生制定治疗方案。

There are many methods that evaluate and predicate the therapeutic effects of tumors, including physical examination, common imaging （X-ray, CT, MRI etc） and tumor marker etc. But these methods have many limits, for example： more subjective, less sensitivity etc. The relative biological features as angiogenesis, apoptosis, hypoxic and proliferation can be reflected by PET early and correctly. So, we can diagnose tumor, predict and evaluate its therapeutic effects by PET used the accorded tracers that reflect the above biological features. Helping clinical doctors to make therapeutic methods.