SARS恢复猴和灭活疫苗免疫实验猴再次感染SARS-CoV研究

Protective Effect of Recovered SARS Monkeys and Vaccinated Monkeys on the Infection of SARS-CoV

目的研究SARS-CoV实验感染恢复猴，以及灭活疫苗免疫猴对SARS—CoV再次感染的疾病状况。方法动物分四组，分别为SARS感染恢复动物组，灭活疫苗免疫不同时间2组和SARS模型对照组。动物分别接种病毒，1～7d进行病毒检测和血清学检测，7d后安乐处死动物，进行病理检测。结果实验感染SARS-CoV猴和灭活疫苗免疫猴均产生了中和抗体，猴体内SARS-CoV复制得到一定程度的抑制，病理变化也比SARS-CoV模型组轻。结论SARS-CoV感染恢复猴对SARS-CoV再次感染有一定抵抗作用；灭活疫苗免疫是预防实验猴感染SARS—CoV的有效方法。

Objective To investigate the protective effect of recovered SARS monkeys and vaccinated monkeys on the Infection of SARS-CoV. Methods To analyze changes of anti-SARA-CoV neutralization antibody, viral detection and pathological changes in lungs of monkeys from groups of SARS recovered monkeys, vaccinated monkeys and SARS model monkeys. Results Groups of SARS recovered monkeys, vaccinated monkeys produced high titer of neutralization antibodies, and inhibited the replication of the virus to a certain extent. The pathological changes of groups of SARS recovered monkeys and vaccinated monkeys were lighter than that in the SARS-monkey group. Conclusions Both groups of SARS recovered monkeys and vaccinated monkeys showed resistance to infection of SARS-CoV