细菌耐药性的分子机制

The Molecular Mechanisms of Bacterial Drug Resistance

伴随着抗生素的广泛应用和不合理的使用,耐药及多重耐药细菌已经严重威胁着人类和动物的健康。从细菌染色体、质粒、转座子等遗传学和产生灭活酶、主动外输、渗透屏障、代谢、靶位改变和生物被膜形成等生物化学方面对细菌产生耐药的分子机制做了介绍,有助于抗菌药物的正确使用,克服或减少细菌耐药性的出现或传播,有利于新抗生药物研究与开发,并建议严格控制抗生素的使用,开发一些天然抗菌肽和特异的细菌疫苗,以控制细菌感染。

The irrational application of antibiotics has seriously threatened the health of human being because of the continuously increasing drug-resistant of bacteria. The report introduces the molecular mechanism from genetics and biochemistry, such as chromosome, plasrnid, transposon, producing inactive enzymes,active efflux,infiltrator barrier,metabolism, change of target position, producing biofilm. The paper is helpful in using antibiotics correctly, reducing occurrence and transmission of drug-resistance of bacteria, and development of new antibiotics. Controlling the applications of the antibiotics strictly, and developing natural antimicrobial peptide and specific bacterial vaccine to control bacterial infection have also been suggested.