b-FGF在恶性黑色素瘤中的表达及其与血管微密度的关系

The expreesion of b-FGFin human malignant melanoma and the relationship between b-FGF and intratumor microvessel density

目的研究碱性成纤维细胞生长因子(b-FGF)在恶性黑色素瘤中的表达及其生物学意义,并探讨其与肿瘤血管形成及淋巴结转移的关系。方法用免疫组化(S-P法)染色技术对42例黑色素瘤石蜡组织标本的b-FGF及肿瘤内微血管密度(MVD)进行检测和分析。结果b-FGF在恶性黑色素瘤中高表达与TNM分期、MVD及淋巴结转移有关(P<0.05)。结论b-FGF在促进肿瘤血管形成和转移方面可能起作用,b-FGF的检测对于判断黑色素瘤转移和预后及治疗具有临床应用价值。

Objective To investigate the expression and distribution of b-FGF in human malignant melanoma （MM）, and to evaluate the relationship between the expression of b-FGF and the biological behaviorof human malignant melanoma（MM）, especially tumor angiogenesis and lymph node metastasis. Methods The expression of b-FGFand IMVD in 42 patients with MM was examined using immunohistochemical methods （SP）, and the relationship between the expression and many clinicopathological parameters were analyzed. Results The positive rates of b-FGF were much bigher in MM than in nevus, b-FGF was associated with IMVD, lymph node metastases, and TNM stage of MM（ P 〈 0.05）. Conclusion b-FGF may play an important role in tumor angiogenesis and lymphatic metastasis of MM, and detection of b-FGF may be a good metastasis and prognostic predictors.