间歇性低浓度氧吸入干预对单纯收缩期高血压患者的疗效观察

The therapeutic effects of intermittent hypoxia therapy in isolated systolic hypertension patients

目的探讨间歇性低浓度氧吸人干预对脑血流速度增快的中青年单纯收缩期高血压(ISH)患者的疗效及可能治疗机制。方法选取大脑中动脉(MCA)血流速度收缩峰值(Vp)增快、搏动指数(P1)正常的中青年单纯收缩期高血压患者76例,将其随机分为治疗组和对照组,每组38例。治疗组患者给予间歇性常压低浓度氧吸入干预,而对照组患者则呼吸自然空气。分别于治疗前、后观察2组患者大脑中动脉Vp、Pl及血压值的变化情况。结果2组患者分别经相应治疗后发现,治疗组患者大脑中动脉Vp值较干预前明显降低,经统计学分析,差异具有统计学意义(p＜0．01),而PI值干预前、后差异无统计学意义(P＞0．05)；收缩压较干预前亦有不同程度降低,经统计学分析,差异有统计学意义(P＜0．01),而舒张压干预前、后差异无统计学意义(P＞0．05)；对照组患者大脑中动脉Vp、PI及血压值干预前、后差异均无统计学意义(P＞0．05)。结论间歇性常压低浓度氧吸入干预能有效缓解单纯收缩期高血压患者的血压,减缓其异常增快的脑血流速度。

Objective To study the therapeutic effects of intermittent hypoxia therapy （IHT） in isolated systolic hypertension （ISH） patients with elevated cerebral blood flow velocity （Vp） , and to explore the mechanisms involved. Methods Seventy-six ISH patients with increasing Vp and normal pulsatility index（PI） of the middle cerebral artery （MCA） were randomly divided into a therapy group and a control group. IHT was administrated in the therapy group, and air in the control group. The Vp and PI of the MCA and blood pressure （BP） were observed before and after treatment. Results Vp and systolic blood pressure （SBP） were significantly reduced after IHT （P 〈 0.01 ） compared with the therapy group＇s scores before treatment, but PI and diastolic blood pressure showed no significant difference. There was no significant change in BP, Vp or PI in the control group before or after treatment. Conclusion IHT has therapeutic effects on ISH by reducing Vp and moderating SBP.