Bid蛋白在骨关节病关节软骨细胞中的表达及意义

Expression of Bid Protein in Osteoarthrosis Articular Chondrocytes and Its Possible Significance

目的研究促凋亡蛋白Bid在正常关节软骨细胞和骨关节病时关节软骨细胞中的表达,探索Bid蛋白在骨关节病发病中的作用。方法取20例髋关节骨关节病行关节置换的关节软骨标本和10例正常关节软骨标本,应用免疫组织化学方法检测Bid蛋白在软骨细胞中的表达。结果Bid蛋白表达阳性率在骨关节病关节软骨细胞中较正常关节软骨细胞高,两者有显著性差异。结论Bid蛋白可能通过参与调控关节软骨细胞凋亡,在骨关节病发病中起作用。

Objective To determine the expression of Bid protein in normal and osteoarthrosis human articular cartilage. Methods Twenty patients with hip osteoarthrosis and 10 patients with normal articular cartilage were obtained. Expression of Bid protein was detected by immunohistochemical analysis. Results The Bid positive cell ratio observed in osteoarthrosis articular cartilage were significantly higher than in the normal articular cartilage. Conclusion Bid may regulate apoptosis of articular chondrocyte and may play an important role in the pathogenic mechanism of osteoarthrosis.