碘伏与碘甘油对大鼠实验性牙龈炎治疗作用的比较

Comparison of Iodophor and Iodine Glycerin in the Treatment of Experimental Rat Gingivitis

目的通过动物实验比较碘伏与碘甘油对牙龈炎的治疗作用。方法采用丝线结扎大鼠牙颈部,辅以高糖饮食造成牙龈炎模型,实验分为正常对照组、牙龈炎模型组、碘伏组与碘甘油组。用药7 d后,测定牙龈局部血流及龈沟液天冬氨酸转氨酶(aspartate aminotransferase,AST)含量的变化。结果模型动物牙龈充血红肿有溃疡和假性牙周袋形成,探诊易出血。牙龈炎局部血流量、血细胞数及龈沟液AST较对照组升高显著(P<0.01)。碘伏组及碘甘油组与模型组比较血流量、血细胞数及AST均有显著降低(P<0.05),碘甘油组血流量及AST含量显著低于碘伏组。结论2种碘制剂对牙龈炎均有治疗作用,碘甘油的治疗作用优于碘伏。

Objective To compare the therapeutic effect of Iodophor and iodine glycerin in treating gingivitis of rats. Methods The gingivitis animal model was made by suturing ligation of the neck on rat teeth and feeding with food containing high sugar. Animals were divided into groups of normal control, gingivitis, Iodophor and iodine glycerin. Local blood flow and aspartate aminotransferase levels were measured in gingival fluid after 7 d treatment. Results The gingiva of rats in gingivitis model group became red and swollen and formed false periodontal pocket. The quantity and cell number of blood flow and the gingival crevicular fluid aspartate aminotransferase （AST） levels in model group increased significantly （P〈0.01） compared with control group. The quantity and cell number of blood flow and the gingival crevicular fluid AST levels in groups of iodophor and iodine glycerin were significantly lower （P〈0.01） than those in model group. The quantity of blood flow and the gingival crevicular fluid AST levels in iodine glycerin group were significantly lower （P〈0.01） than those in iodophor group. Conclusion The two drugs were effective in treating experimental gingivitis, and iodine glycerin is more effective than iodophor.