磷脂酶C信号通路与M通道调控

Phospholipase C signaling pathway and M channel modulation

M型通道作为一种外向型电压依赖型钾通道,在调节神经系统兴奋性方面发挥着重要作用。M通道的功能受到体内多种因素的调节,其功能失常往往导致神经系统疾病。自M电流被发现后的20多年时间里,人们对其调节机制进行了大量深入细致的研究。磷脂酶C信号转导通路目前被认为在M通道的调控过程中发挥了重要作用。因此本文将对这一信号通路中各个环节对M通道的调节作用及目前一些最新的研究进展进行综述。

As an outward, voltage-dependent potassium channel, M type channel is crucial in the regulation of neuronal excitability; it is modulated by a variety of factors in vivo and its dysfunction often results in neuronal system diseases. Great efforts have been made to elucidate the mechanism underlying M channel modulation since its discovery decades ago. It is generally accepted that the Phospholipase C （PLC） signaling pathway plays a significant role in the M channel modulation. This review highlights the relationship between PLC signaling pathway and M channel modulation, as well as some recent progresses in the research of this field.