摘要
研究复方牛胎肝提取物联合二甲双胍对非酒精性脂肪性肝炎的治疗作用。将68例非酒精性脂肪性肝炎患者随机分成两组,每组34例,试验组给予牛胎肝提取物联合二甲双胍治疗;对照组给予二甲双胍治疗,疗程均为3个月。治疗前后测定各组患者肝功能指标:ALT、AST、GGT;血脂指标:TG、TC、HDL-C;血清肝纤维化指标: HA、LN、CⅣ、PCⅢ。治疗后两组患者肝功能指标均明显下降,试验组下降尤为明显(P<0.01);治疗后试验组血清TG、TC均明显下降(P<0.01),HDL-C明显上升(P<0.01),对照组仅TG下降明显(P<0.01);治疗后试验组HA、LN、PCⅢ下降,与对照组比较差异有显著性(P<0.05)。复方牛胎肝提取物联合二甲双胍是治疗非酒精性脂肪性肝炎的有效方法。
This assay was to assess therapeutic effect of compound fetal bovine liver extract with metformin on nonalcoholic steatohepatitis. 68 nonalcoholic steatohepatitis were randomly divided into experiment group ( n = 34, treated with compound fetal bovine liver extract with metformin )and control group (n = 34, treated with metformin). After 3 months, serum ALT, AST, GGT, TG, TC, HCL- C, HA, LN, CIV, Pcm were detected. From the results, we know that the index of hepatic function reduced obviously both in experiment group and control group at the endpoint, especially in the former group ( P 〈0. 05 ). The level of TG, TC decreased markedly in experiment group. But in control group only the level of TG decreased after treatment. The level of HDL - C increased markedly only in experiment group (P 〈0. O1 ). The level of se- rum HA, LN, PC Ⅲ in experiment group decreased markedly. So we draw the conclusion that the treatment of fetal bovine liver extract combined with metformin was effective for nonalcoholic steatohepatitis.
出处
《临床肝胆病杂志》
CAS
2006年第5期354-356,共3页
Journal of Clinical Hepatology