239株肺部感染病原菌的分离及其耐药性分析

Analysis of 239 Strains of Lung Infection Pathogens and Drug Resistance

目的了解我院肺部感染病原菌的分布及耐药现状,为临床治疗应用抗生素提供依据。方法对本院2004年至2005年368例肺部感染患者的痰菌培养及药物敏感试验结果进行研究分析,对分离出的大肠埃希菌和肺炎克雷伯菌进行ESBLS检测。结果368例患者痰培养分离出病原菌11种共239株,阳性率为64.9%,50岁以上患者占73.7%,其中革兰阴性(G-)菌占总菌株的76.6%;前四位菌种分别为肺炎克雷伯菌,大肠埃希菌,铜绿假单胞菌,鲍曼不动杆菌;药敏结果显示G-菌对抗生素的耐药率呈上升趋势。结论肺部感染以老年患者为主,病原菌以G-菌为主,且其耐药率呈上升趋势。提示临床应合理选择使用抗生素,注意去除老年患者感染的危险因素。

Objects To know the distribution and currence of drug resistance of lung infection pathogen in my hospital and to provide a basis of using antibiotics for clinical treatment. Methods To study and analyse the results of sputum culture and drugs sensitivity test of 368 cases hospital patients of pulmonary infection during 2004 to 2005. And ESBLS test the isolating Escherichia coli and Klebsiella pneumoniae . Results 239 strains with a total of l 1 pathogens were iso lated and sputum cultured during 368 patients. The positive rate is 64.9 %. The over 50s accounted for 73.7%, and G^- bacteria accounted for 76.6%. The top four strains are Klebsiella pneumoniae and Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii; The susceptibility tests showed G^- bacteria resistance rate to antibiotics is rising. Conclusion The main patients with pulmonary infection are elderlies, and main pathogens are G-acteria, and their resistance grows. The results suggest that the use of antibiotics should be more selective, and we should pay more attention to removing risk factors for infection in elderly patients.