期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Apollon和Smac凋亡基因在白血病中的表达 被引量：2

Expression of apollon and smac in leukemia
原文传递
导出
摘要 Apollon是新近发现的IAP家族成员,主要通过结合Smac,HtrA2以及caspase等3种机制发挥其抑凋亡作用。着重阐述了Apollon及Smac基因与凋亡的关系及在白血病中的表达。 Apollon is a now potent member of inhibitor of apoptosis proteins（IAP）family, which inhibits apoptosis by bind and inhibit smac, HtrA2 and caspase-9. This study intended to investigate the expression of apollon and smac in leukemia and their relation to apoptosis.
作者 尹婉宜 林凤茹
机构地区 河北医科大学第二医院血液内科
出处 《白血病．淋巴瘤》 CAS 2006年第5期393-395,共3页 Journal of Leukemia & Lymphoma
关键词 APOLLON SMAC 凋亡基因 白血病 Apollon Smac Leukemia
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Chen Z,Naito M,Hori S,et al.A human IAP-Family gene,apollon,expressed in human brain cancer cells[J].Biochem Biophys Res Commun,1999,264(3):847-854.
  • 2Bartke T,Pohl C,Pvrowolakis G,et al.Dual role of BRUCE as an antiapoptotic IAPand a chimeric E2/E3 ubiquitin ligase[J].Molecular Cell,2004,14(1):801-811.
  • 3Hauser H,Bardroff M,Pyrowolakis G,et al.A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors[J].Cell Biol,1998,141(6):1415-1422.
  • 4Hao Y,Sekine K,Kawabata A,et al.Apollon ubiquitinates SMAC and caspase-9,and has an essential cytoprotection function[J].Nat Cell Biol,2004,6(9):849-860.
  • 5Sekine K,Hao Y,Suzuki Y,et al.HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells[J].Biochem Biophys Res Commun,2005,330(1):279-285.
  • 6Qiu X B,Goldberg A L.Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member,ErbB3[J].Proc Natl Acad Sci USA,2002,99(23):14843-14848.
  • 7Qiu X B,Markant S L,Yuan J,et al.Nrdp1-mediated degradation of the gigantic IAP,BRUCE,is a novel pathway for triggering apoptosis[J].Embo,2004,23(4):800-810.
  • 8Chai J,Du C,Wu J W,et al.Structural and biochemical basis of apoptosis activation by Smac/DIABLO[J].Nature,2000,406(6798):855-862.
  • 9Shi Y.A conserved tetrapeptide motif:potentiating apoptosis through IAP-binding[J].Cell Death Differ,2002,9(2):93-95.
  • 10Huang Y,Park Y C,Rebecca L R,et al.Structural basis of caspase inhibition by XIAP:differential roles of linker versus the BIR domain[J].Cell,2001,104(5):781-790.

同被引文献16

引证文献2

二级引证文献5

白血病．淋巴瘤
2006年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部