介入化疗结合直线加速器放射治疗中晚期食管癌

Interventional Radio Chemotherapy of Advanced Esophageal Carcinoma Combined with Linear Accelerator Radiotherapy

目的 评价介入化疗结合直线加速器放射治疗中晚期食管癌的疗效。方法 2002年3月～2004年3月我们收治的食管癌患者143例，随机分为介入化疗结合直线加速器放射治疗组（实验组）72例和常规放疗组（对照组）71例。实验组分别于放射治疗的前及放射治疗20次后行介入动脉灌注化疗；对照组行单独直线加速器放疗。两组放射治疗均采用常规分割，每周5次，每次2．0Gy，总剂量为60Gy。结果 实验组和对照组治疗结束后肿瘤完全消失率分别为75％和55％（P〈0．05），1年局部控制率和生存率分别为74％，48％和92％，76％（P〈0．05）。结论 介入化疗结合直线加速器放射治疗中晚期食管癌可提高疗效。

Objective To evaluate curative efficiency of super selective esophageal intra-arterial infusion chemotherapy combined with radiotherapy for advanced esophageal carcinoma. Methods 143 patients with advanced esophageal carcinoma were randomly divided into 2 groups （72 in treatment group and 71 in control group）： Treatment group was treated by super selective esophageal intra-arterial infusion chemotherapy combined with radiotherapy; Control group was treated with radiotherapy alone. All patients of two groups managed conventional fraction radiation： 2.0Gy per fraction, five fraction a week with the total doses of 60 Gy, and followed up for 12 months. Results For the treatment group and control group, esophageal lesion complete relief rates were respectively 75 % and 55 % （P 〈 0.05）, The one-year local control rates were respectively74%, 48% （ P 〈 0.05） and one year survival rates were respectively 92% ,76% （ P 〈 0.05）. Conclusion It shows significant efficiency for super selective esophageal intra-arterial infusion chemotherapy combined with radiotherapy for advanced esophageal carcinoma.