表皮生长因子及其受体与胃肠道疾病

Epidermal growth factor and its receptor (EGFR) in gastrointestinal tract

表皮生长因子(EGF)是最重要的促细胞生长因子之一,消化道中EGF含量远远高于血循环中的浓度。近年研究表明,EGF对许多胃肠道良性疾患有治疗作用,同时也发现EGF和EGFR拮抗剂可以影响恶性肿瘤的发生、发展和消退。

Epidermal growth factor（EGF） is one of the most important growth factor related with cell proliferation and the concentration of EGF is higher in gastrointestinal tract than in blood circulation. In recent years, the study has confirmed the effect of EGF in treating the benign diseases of gastrointestinal tract, and some research works also find that EGF and the antagon of EGFR can contribute to the occurrence, development or decrement of the gastrointestinal tumors.