氯诺昔康对慢性关节炎治疗的实验研究

The effects of lornoxicam on chronic arthritis in rat.

目的在大鼠慢性关节炎模型上,研究关节腔内注射氯诺昔康对慢性关节炎的疗效。方法大鼠慢性关节炎模型上,通过观察治疗前后关节影像学和病理学变化,测定治疗前后关节直径、疼痛评分、运动评分研究关节腔内注射氯诺昔康对慢性关节炎的治疗效果。结果(1)氯诺昔康治疗两周后影像学显示炎症减轻,病理学显示有新生关节软骨形成；(2)氯诺昔康治疗两周运动评分高于无治疗组(P<＜0．05),踝关节直径、疼痛评分低于无治疗组(P＜0．05)。结论关节腔内注射氯诺昔康可减轻慢性关节炎,还可促进受损关节的修复。

Objective To research the effect of injection of lornoxicam in joint cavity for the treatment of rat chronic arthritis. Methods Injection of complete Freund＇s adjuvant into the right tibio-tarsal joint produced a reliable monoarthritic model. In lornoxicam group, the lornoxicam 4mg＂ kg-＇ was injected into the arthritic cavity and x-ray films, pathological sections, the diameters of the right ankle joint, and the behavior of rats （arthritic flexion pain test, exercise test） were made, evaluated and compared in order to assess the effect of the drugs. Results （1） The renascent cartilage cells were seen in pathological section in lornoxicam group after 2-week treament. （2） After 2-week treatment, the diameters of the right ankle joint in lornoxicam group were significantly lower than non-treating group （P 〈 0.05） , scores of arthritic flexion pain test and exercise test were significantly different between non-treating group and lornoxicam group （P 〈 0.05） Conclusion Repeated injections of lornoxicam in arthritic joint cavity produce analgesia and accderate joint recovery.