原发性胆汁性肝硬化血清学免疫功能分析

Immunological characteristics of primary biliary cirrhosis patients in serum.

目的总结原发性胆汁性肝硬化(PBC)的血清学免疫功能特点。方法分析16例PBC患者一般资料、其他免疫性疾病史、临床表现、血清学免疫功能及肝组织病理。结果本组女性13例,男性3例,平均年龄(59．44±9．93)岁,血清学免疫功能检出情况：免疫球蛋白：IgM升高8例(8/16,50%),IgA升高7例(7/16,43．8%)．IgG升高5例(5/16,31．3%)。非特异性抗体：抗核抗体(ANA)阳性率最高(12/16,75%),其中包括抗线粒体型(5/16,31．3%)．Jo-1型(3/16．18．8%),抗SSA/SSB型(2/16,12．5%)；双链DNA(DSDNA)阳性率12．5%(2/16)。特异性自身抗体：抗线粒体抗体M2亚型似(AMA-M2)阳性率较高(6/16,37．5%),其他阳性有抗肝/肾微粒体抗体(LKM1)(3/16,18．8%),抗核心蛋白抗体(GP210)(2/16．12．5%)。结论PBC患者血清学免疫功能明显异常。

Objective To summary the immunological characteristics of serum in primary biliary cirrhosis（PBC） patients. Methods Clinical data of 16 cases of PBC were reviewed, including general status, the history of other immune diseases, the clinical manifestation, immunological function in serum, and pathologic data of hepatic tissue. Result Among 16 patients, 13 were female, the mean age was （59.44＋9.93） years old. The major symptoms in these patients were jaundice （81.3%） and pruritus （37.5%） . Immune function was abnor- mal： IgM in 8 cases （50%） , IgA in 7 cases （43.8%） , IgG in 5 cases （31.3%） . Non-specific antibody： positivity of antinucIear antibody （ANA） was 75%, among them, anti-mitoehondrlaI subtype was 31.3%, Jo- 1 subtype was 18.8%, SSA/SSB antibody subtype was 12.5%. 12.5% of them were double strands DNA （DS- DNA） . Anti-mitochondrial antibody M2 subtype （AMA-M2） was 37.5%, liver/kidney microsomal antibodyl （LKM1） was 18.8%, core protein antibody （GP210） was 12.5%. Conclusion Immune function of serum in primary biliary cirrhosis patients was abnormal obviously.